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Scientists uncover binding secret behind protein ‘superglue’

June 16, 2019 dna 0
Scientists have pinpointed how a special class of plant-derived enzymes, known as peptide ligases, work to join proteins together — an important process in the development of drugs, for example in specifically attaching a chemotherapy drug to an antibody that recognizes tumor markers to target cancer cells. Using this knowledge, they created a recombinant enzyme that is 3,000 times faster than known types of ligases.
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Life in Antarctica’s ice mirrors human disease

June 16, 2019 dna 0
Mapping tens of thousands of genes from a group of Antarctic fishes called notothenioids, a team of researchers has discovered that the massive amount of genetic change required for life in the Antarctic occurred long before the Antarctic cooled. These genetic changes not only have major implications for understanding the evolution of Antarctica’s unusual animals, but also highlight that some key adaptations used by fishes mirror the genetics of human bone diseases such as osteoporosis.