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Study merges big data and zebrafish biology to reveal mechanisms of human disease

April 24, 2019 dna 0
In a series of studies that volleyed between large databases and research in zebrafish, investigators have discovered a link between vascular biology and eye disease. The research uncovered an unexpected role for the gene GRIK5, and it showcases a new paradigm for using biobanks, electronic health records and zebrafish to discover the genetic mechanisms that contribute to human disease.
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Direct-to-Consumer Genetic Testing’s Red Herring: “Genetic Ancestry” and Personalized Medicine.

April 24, 2019 dna 0
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Direct-to-Consumer Genetic Testing’s Red Herring: “Genetic Ancestry” and Personalized Medicine.

Front Med (Lausanne). 2019;6:48

Authors: Blell M, Hunter MA

Abstract
The growth in the direct-to-consumer genetic testing industry poses a number of challenges for healthcare practice, among a number of other areas of concern. Several companies providing this service send their customers reports including information variously referred to as genetic ethnicity, genetic heritage, biogeographic ancestry, and genetic ancestry. In this article, we argue that such information should not be used in healthcare consultations or to assess health risks. Far from representing a move toward personalized medicine, use of this information poses risks both to patients as individuals and to racialized ethnic groups because of the way it misrepresents human genetic diversity.

PMID: 30984759 [PubMed]