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New ‘SLICE’ tool can massively expand immune system’s cancer-fighting repertoire

November 30, 2018 dna 0
Researchers have devised a CRISPR-based system called SLICE, which will allow scientists to rapidly assess the function of each and every gene in ‘primary’ immune cells — those drawn directly from patients. The new method, described in the Nov. 15 issue of Cell, provides researchers with a powerful tool that will guide their decision-making when determining how best to engineer immune cells to fight cancer and a host of other diseases.
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Impaired cellular force transmission a cause for valvular heart disease

November 30, 2018 dna 0
About three per cent of the world’s population is affected by valvular heart diseases. It is also the most common cause of heart surgery, as no drug-based treatment is available. Recent research has shed light on the molecular mechanism on valvular disease that is caused by a genetic mutation in Filamin gene. The result of the research will help to further investigate the mechanism by which the medical condition progress and to develop new treatments.