In research that casts cells as curators of their own history, scientists have discovered that adult tissues retain a memory, inscribed on their DNA, of the embryonic cells from which they arose. The discovery led to one even more intriguing — that the memory is fully retrievable: under certain conditions, cells can play the story of their development in reverse to switch on genes that were active in the fetal state.
A new study suggests that there could be a way to bypass barriers to making CRISPR gene-editing treatments a viable option. Researchers found that using more-precise gene-editing technology that induces fewer breaks in DNA may keep stem cells’ natural damage-response pathways under control.
Despite efforts to include diversity in research, people of European ancestry continue to be vastly overrepresented and ethnically diverse populations largely excluded from human genomics research, according to the authors of a new commentary. This lack of diversity in studies has serious consequences for science and medicine.
A study conducted in C. elegans nematode roundworms may lead to improved treatment of a rare human genetic disorder that causes severe neurological symptoms leading to death in early childhood.
Researchers have uncovered a ‘druggable’ mechanism of pathological tau protein aggregation — a significant advance toward finding an effective treatment for early-stage neurodegenerative diseases.
What makes a biological clock tick? According to a new study the surprising answer lies with a gene typically associated with stem and cancer cells.
Pathogenic gene mutations causing a type of intractable skin disease can be eliminated from some parts of patients’ skin as they age, according to researchers. This represents a form of natural gene therapy.
The compound called Cugamycin works by recognizing toxic RNA repeats and destroying the garbled gene transcript.
Researchers report findings from a study in which they measured levels of estrogen byproducts in urine from a group of women with breast cancer. Relative levels of ”good” versus ”bad” estrogen byproducts were linked to survival.
With the specter of increased resistance to antibiotics, the scientific community is feeling pressure to find new ways to treat bacteria like Group A Streptococcus. And it appears that an international group of scientists has gained some insight into this microbial enemy — and hope of a vaccine.