Researchers found that one mechanism by which antibiotics induce drug-resistance mutations in bacteria is by triggering the generation of high levels of toxic molecules called reactive oxygen species (ROS). Additionally, treatment with a ROS-reducing drug approved by the US Food and Drug Administration for other purposes prevented these antibiotic-induced mutations.
Scientists have discovered a new mechanism of gene transcription in tumor cells. Their study identifies novel strategies to develop innovative anti-cancer drugs.
In research that casts cells as curators of their own history, scientists have discovered that adult tissues retain a memory, inscribed on their DNA, of the embryonic cells from which they arose. The discovery led to one even more intriguing — that the memory is fully retrievable: under certain conditions, cells can play the story of their development in reverse to switch on genes that were active in the fetal state.
A new study suggests that there could be a way to bypass barriers to making CRISPR gene-editing treatments a viable option. Researchers found that using more-precise gene-editing technology that induces fewer breaks in DNA may keep stem cells’ natural damage-response pathways under control.
Despite efforts to include diversity in research, people of European ancestry continue to be vastly overrepresented and ethnically diverse populations largely excluded from human genomics research, according to the authors of a new commentary. This lack of diversity in studies has serious consequences for science and medicine.
A study conducted in C. elegans nematode roundworms may lead to improved treatment of a rare human genetic disorder that causes severe neurological symptoms leading to death in early childhood.
Researchers have uncovered a ‘druggable’ mechanism of pathological tau protein aggregation — a significant advance toward finding an effective treatment for early-stage neurodegenerative diseases.