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Anti-evolvability drugs could slow antibiotic resistance in bacteria

March 31, 2019 dna 0
Researchers found that one mechanism by which antibiotics induce drug-resistance mutations in bacteria is by triggering the generation of high levels of toxic molecules called reactive oxygen species (ROS). Additionally, treatment with a ROS-reducing drug approved by the US Food and Drug Administration for other purposes prevented these antibiotic-induced mutations.
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Study finds cells maintain a complete molecular ‘memory’ of their embryonic origins

March 31, 2019 dna 0
In research that casts cells as curators of their own history, scientists have discovered that adult tissues retain a memory, inscribed on their DNA, of the embryonic cells from which they arose. The discovery led to one even more intriguing — that the memory is fully retrievable: under certain conditions, cells can play the story of their development in reverse to switch on genes that were active in the fetal state.
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Using more-specific ‘genetic scissors’ may avoid problems associated with gene editing

March 31, 2019 dna 0
A new study suggests that there could be a way to bypass barriers to making CRISPR gene-editing treatments a viable option. Researchers found that using more-precise gene-editing technology that induces fewer breaks in DNA may keep stem cells’ natural damage-response pathways under control.
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Western bias in human genetic studies is ‘both scientifically damaging and unfair’

March 31, 2019 dna 0
Despite efforts to include diversity in research, people of European ancestry continue to be vastly overrepresented and ethnically diverse populations largely excluded from human genomics research, according to the authors of a new commentary. This lack of diversity in studies has serious consequences for science and medicine.