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Structure of a ‘master switch’ controlling cell division

May 31, 2019 dna 0
Unregulated cell division is a hallmark of cancer, and one of the key proteins involved in controlling cell division is called FoxM1. Abnormal activation of FoxM1 is a common feature of cancer cells and is correlated with poor prognosis, metastasis, and resistance to chemotherapy. Now researchers have determined the structure of this protein — a kind of ‘master switch’ for cell division — in its inactive or ‘off’ conformation.
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Direct-to-Consumer Genetic Testing’s Red Herring: “Genetic Ancestry” and Personalized Medicine.

May 31, 2019 dna 0
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Direct-to-Consumer Genetic Testing’s Red Herring: “Genetic Ancestry” and Personalized Medicine.

Front Med (Lausanne). 2019;6:48

Authors: Blell M, Hunter MA

Abstract
The growth in the direct-to-consumer genetic testing industry poses a number of challenges for healthcare practice, among a number of other areas of concern. Several companies providing this service send their customers reports including information variously referred to as genetic ethnicity, genetic heritage, biogeographic ancestry, and genetic ancestry. In this article, we argue that such information should not be used in healthcare consultations or to assess health risks. Far from representing a move toward personalized medicine, use of this information poses risks both to patients as individuals and to racialized ethnic groups because of the way it misrepresents human genetic diversity.

PMID: 30984759 [PubMed]