With the help of the common fruit fly (D. melanogaster), which ages quickly because it only lives about 60 days, neuroscientists provide insights into healthy aging by investigating the effects of a foraging gene on age and stress tolerance.
Scientists have pinpointed how a special class of plant-derived enzymes, known as peptide ligases, work to join proteins together — an important process in the development of drugs, for example in specifically attaching a chemotherapy drug to an antibody that recognizes tumor markers to target cancer cells. Using this knowledge, they created a recombinant enzyme that is 3,000 times faster than known types of ligases.
New research uncovers leading mechanisms of separation of active from inactive fractions of the genome in the cell nucleus and turns our picture of the nucleus upside down.
A new protein involved in Alzheimer’s disease (AD) has been identified by researchers. CAPON may facilitate the connection between the two most well-known AD culprits, amyloid plaques and tau pathology, whose interactions cause brain cell death and symptoms of dementia.
Research provides a possible new reason why human disease burden increases so sharply from the sixth decade of life onward as health-protective mechanisms disappear.
Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting millions of people worldwide. Characterized by accumulation of the protein alpha-synuclein, there is currently no cure for PD. Scientists have now developed a novel treatment effectively ameliorated disease symptoms in a mouse model of PD.
A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of attacking it, researchers report.
A new study has deciphered a complex molecular conversation between cancer and immune cells that is key to orchestrating the successful invasion of tumors by T cells that kill cancer cells.
Mapping tens of thousands of genes from a group of Antarctic fishes called notothenioids, a team of researchers has discovered that the massive amount of genetic change required for life in the Antarctic occurred long before the Antarctic cooled. These genetic changes not only have major implications for understanding the evolution of Antarctica’s unusual animals, but also highlight that some key adaptations used by fishes mirror the genetics of human bone diseases such as osteoporosis.
Researchers have developed a two-step combination therapy to destroy cancer cells. They show the superior therapeutic effectiveness of the ‘one-two punch’ on cells of ovarian cancer patients, based on manipulation of the state of cellular aging.