Parkinson’s disease (PD) is a progressive neurodegenerative disease affecting millions of people worldwide. Characterized by accumulation of the protein alpha-synuclein, there is currently no cure for PD. Scientists have now developed a novel treatment effectively ameliorated disease symptoms in a mouse model of PD.
A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of attacking it, researchers report.
A new study has deciphered a complex molecular conversation between cancer and immune cells that is key to orchestrating the successful invasion of tumors by T cells that kill cancer cells.
Mapping tens of thousands of genes from a group of Antarctic fishes called notothenioids, a team of researchers has discovered that the massive amount of genetic change required for life in the Antarctic occurred long before the Antarctic cooled. These genetic changes not only have major implications for understanding the evolution of Antarctica’s unusual animals, but also highlight that some key adaptations used by fishes mirror the genetics of human bone diseases such as osteoporosis.
Researchers have developed a two-step combination therapy to destroy cancer cells. They show the superior therapeutic effectiveness of the ‘one-two punch’ on cells of ovarian cancer patients, based on manipulation of the state of cellular aging.
Natural products make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class. Their size and complexity has made it difficult to emulate on Nature’s success in the laboratory. By completing a complex molecular synthesis of these compounds attached to a unique identifying DNA strand, Chemists have built a rich collection of natural product-like macrocycles that can be mined for new medicines.
Using advanced technologies to explore the inner workings of bacteria, biologists have provided the first example of cargo within bacteriophage cells transiting along treadmill-like structures. The discovery demonstrates that bacteria have more in common with sophisticated human cells than previously believed.
The man is implicated in about half of all cases of infertility. Despite the known importance of genetic factors in the non-production of sperm, only about 25% of these cases can be explained currently. Now a study has uncovered new potential genetic causes, and this discovery will help to develop better diagnostic tests for male infertility.
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