Since the discovery that the gut microbiome may play a role in the development of Parkinson’s disease (PD), this fresh scientific approach has produced varying results. Scientists compare results of current research and provide recommendations to increase the comparability and utility of these studies with a view towards improving patient outcomes.
Scientists report the discovery of ‘hyperhotspots’ in the human genome, locations that are up to 170-times more sensitive to ultraviolet radiation (UV) from sunlight compared to the genome average.
Bacteria associated with Crohn’s disease rely on multiple stress responses to survive, multiply, and tolerate antibiotics within white blood cells called macrophages, according to a new study.
Deletion of the gene that codes for an enzyme called GSTM1 increased kidney injury in mice with hypertension and kidney disease, but supplementing the diet with broccoli powder lessened kidney injury in the genetically altered mice. In humans, high consumption of broccoli and other cruciferous vegetables was linked with a lower risk of kidney failure, primarily in individuals lacking GSTM1.
Following a nearly 25-year search across three continents, parents of a pair of sisters — who as children slowly became paralyzed from the waist down — finally have a diagnosis. Thanks to a chance viewing on French TV of a story about another physically disabled child who regained her mobility after being diagnosed at TGen, the parents of the two sisters contacted TGen, hoping to end their decades-long diagnostic odyssey.
Scientists have uncovered new molecular drivers of Parkinson’s disease using a sophisticated statistical technique called multiscale gene network analysis (MGNA). The team was also able to determine how these molecular drivers impact the functions of genes involved in the disease. The results may point to potential new treatments.
First direct analysis of pathogenic sequence repeats in the human genome.
A comparison of mouse Alzheimer’s disease models shows changes in the number of cells and the genes they express remain consistent throughout all stages of the disease.