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New roles found for Huntington’s disease protein

January 31, 2020 dna 0
A research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative disorder known as Huntington’s Disease. Using genetic mouse models, they have discovered that neurons in the striatum, a brain area involved in controlling movement, require the huntingtin gene for regulating the body’s movements, maintaining cell health during aging, and developing functioning connections between cells.
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‘Jumping genes’ help stabilize DNA folding patterns

January 30, 2020 dna 0
The DNA molecule inside the nucleus of any human cell is more than six feet long. To fit into such a small space, it must fold into precise loops that also govern how genes are turned on or off. New research indicates that ‘jumping genes’ play a surprising role in stabilizing the 3D folding patterns of the DNA molecule inside the cell’s nucleus.
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Hundreds of students publish encyclopedia of 1,000 genes linked to organ development

January 30, 2020 dna 0
A research team including 245 undergraduates has published an encyclopedia of more than 1,000 genes, including 421 genes whose functions were previously unknown. The research, conducted in fruit flies, should be useful to scientists studying genes involved in sleep, vision, memory and many other processes in humans.