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World’s first congenital pituitary hypoplasia model developed using patient-derived iPS cells

February 28, 2020 dna 0
Researchers have developed the world’s first congenital pituitary hypoplasia (CPH) model using patient-derived iPS cells. The research group succeeded in using the model to illuminate the mechanisms underlying CPH. The team has been attempting to apply this model to other pituitary diseases and drug discovery.
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Exploring a genome’s 3D organization through a social network lens

February 28, 2020 dna 0
Computational biologists have taken an algorithm used to study social networks, such as Facebook communities, and adapted it to identify how DNA and proteins are interconnected into communities within the cell nucleus. The behavior of these communities may prove key to understanding basic cellular processes and disease mechanisms, such as aging and cancer development.
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Nanosize device ‘uncloaks’ cancer cells in mice and reveals them to the immune system

February 28, 2020 dna 0
Scientists report they have designed and successfully tested an experimental, super small package able to deliver molecular signals that tag implanted human cancer cells in mice and make them visible for destruction by the animals’ immune systems. The new method was developed, say the researchers, to deliver an immune system ‘uncloaking’ device directly to cancer cells.
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Huntington’s disease-causing DNA repeat mutations reversed in the lab

February 28, 2020 dna 0
An international team of researchers identifies a compound that corrects genetic abnormalities involved in the onset and progression of Huntington’s disease for which there is no definitive treatment. They successfully reversed disease-causing DNA expansion mutations with no off-target effects in the lab. They hope that their discovery may help treat other DNA repeat diseases like myotonic dystrophy.