Scientists have found that a chemical mark on histones – a key protein involved in the function of our DNA – occurs naturally under nutrient-limited conditions as cells change the way they make energy, and serves to repress genes that would otherwise drive cell growth. The chemical mark is called crotonylation, and until now its function has not been well understood.
Since the discovery that the gut microbiome may play a role in the development of Parkinson’s disease (PD), this fresh scientific approach has produced varying results. Scientists compare results of current research and provide recommendations to increase the comparability and utility of these studies with a view towards improving patient outcomes.
A new study finds that neurons affected in Parkinson’s disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wrecks havoc in the brain, as well as ideas for new treatments.
Scientists report the discovery of ‘hyperhotspots’ in the human genome, locations that are up to 170-times more sensitive to ultraviolet radiation (UV) from sunlight compared to the genome average.
Bacteria associated with Crohn’s disease rely on multiple stress responses to survive, multiply, and tolerate antibiotics within white blood cells called macrophages, according to a new study.
Zika virus infection in the womb produces altered immune responses and sex-specific brain abnormalities in apparently healthy pig offspring, according to a new study.
Following a nearly 25-year search across three continents, parents of a pair of sisters — who as children slowly became paralyzed from the waist down — finally have a diagnosis. Thanks to a chance viewing on French TV of a story about another physically disabled child who regained her mobility after being diagnosed at TGen, the parents of the two sisters contacted TGen, hoping to end their decades-long diagnostic odyssey.
Deletion of the gene that codes for an enzyme called GSTM1 increased kidney injury in mice with hypertension and kidney disease, but supplementing the diet with broccoli powder lessened kidney injury in the genetically altered mice. In humans, high consumption of broccoli and other cruciferous vegetables was linked with a lower risk of kidney failure, primarily in individuals lacking GSTM1.