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Researchers suggest a pathway to reverse the genetic defect of Friedreich’s ataxia

January 20, 2020 dna 0
Scientists have identified a molecular mechanism that could reverse the genetic defect responsible for Friedreich’s ataxia, a neurodegenerative disease that leaves its victims with difficulty walking, a loss of sensation in the arms and legs and impaired speech. The researchers discovered that the genetic anomaly that causes the disease — the multiple repetition of a three letter DNA sequence — could potentially be reversed by enhancing a natural process that contracts the repetitive sequences in living tissue.
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Nanoparticles deliver ‘suicide gene’ therapy to pediatric brain tumors growing in mice

January 20, 2020 dna 0
Researchers report that a type of biodegradable, lab-engineered nanoparticle they fashioned can successfully deliver a ”suicide gene” to pediatric brain tumor cells implanted in the brains of mice. The poly(beta-amino ester) nanoparticles, known as PBAEs, were part of a treatment that also used a drug to kill the cells and prolong the test animals’ survival.
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BPA activates immune response in mice that passes down through generations

January 19, 2020 dna 0
Some plastic food and beverage containers still contain bisphenol A (BPA), which can mimic the hormone estrogen. Although experts say that small amounts of BPA detected in foods are unlikely to cause problems, some people worry that constant low-level exposures could have health effects, especially for developing fetuses, infants and children. Now, researchers report that in mice, BPA activates an immune response that persists for at least three generations.