While sifting through the bacterial genome of salmonella, food scientists discovered mcr-9, a new stealthy, jumping gene so diabolical and robust that it resists one of the world’s few last-resort antibiotics.
A genetic variation known to affect sickle cell disease might be the reason why some college football players experience adverse clinical outcomes during periods of extreme physical exertion and others do not.
Researchers have succeeded in creating a ‘protein cage’ — a nanoscale structure that could be used to deliver drugs to specific places of the body — that can be readily assembled and disassembled.
Feeding mosquitoes sugar makes them less attracted to humans, a response that is regulated by the protein vitellogenin, according to a new study.
Using stem cells derived from six people, researchers recapitulated retinal cells in the lab. This ‘eye-in-a-dish’ model allowed them to identify genetic variants that cause age-related macular degeneration, a common cause of vision loss.
Researchers find that ‘waves’ of Hes1 and Ascl1 gene expression control the quiescent and active state of adult neural stem cells. Hes1 expression promotes quiescence and suppresses Ascl1, and knocking out Hes1 increases Ascl1 expression and subsequent adult neural stem cell activation.
Researchers have discovered a chink in the armor of the tumor cells of glioblastoma, a lethal brain cancer. Alongside the finding, the researchers also came up with a method for attacking this vulnerability. The results gained in experiments conducted with cell cultures and a mouse model are promising.
In recent years, it has become increasingly clear to researchers that the protein galectin-3 is involved in inflammatory diseases in the brain. A study now shows the de facto key role played by the protein in Alzheimer’s disease. When the researchers shut off the gene that produces this protein in mice, the amount of Alzheimer’s plaque and the inflammatory load both decreased.
Every summer, tens of thousands of newly minted doctors start the most intense year of their training: the first year of residency, also called the intern year. A new study suggests that the experience will make their DNA age six times faster than normal. And the effect will be largest among those whose training programs demand the longest hours.