New generation of therapeutics based on understanding of aging biology show promise for Alzheimer’s disease

A scientific strategy that explores therapeutic targets based on the biology of aging is gaining ground as an effective approach to prevent and treat Alzheimer’s disease.
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Scientists cut main heart disease risk locus out of DNA by genome editing

Scientists have made a major breakthrough in unveiling the major genetic risk factor for heart disease by precisely cutting the DNA culprit from the genome, which prevents blood vessel cell abnormalities related to these devastating diseases.
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Classifying brain microglia: Which are good and which are bad?

Microglia are important to brain function, and also seem to play a role in disease. New work offers the most comprehensive accounting of brain microglia to date and opens a new chapter in brain exploration. The researchers performed RNA sequencing of 76,000 individual cells — the most comprehensive accounting to date — and spatially mapped them. Their findings could help scientists tell whether microglia are contributing to disease or trying to repair the brain, informing treatment strategies.
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Scientists design way to track steps of cells’ development

Scientists have developed a new tool described as a ‘flight data recorder’ for developing cells, illuminating the paths cells take as they progress from one type to another. This cellular tracking device could one day help scientists guide cells along the right paths to regenerate certain tissues or organs, or help researchers understand the wrong turns some cells might take on their way to becoming cancerous.
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Not one disease: Researchers classify Alzheimer’s patients in six subgroups

Researchers studying Alzheimer’s disease have created an approach to classify patients with Alzheimer’s disease, a finding that may open the door for personalized treatments.
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