One of the great mysteries of neuroscience may finally have an answer: Scientists have identified a potential explanation for the mysterious death of specific brain cells seen in Alzheimer’s, Parkinson’s and other neurodegenerative diseases.
View More Brain discovery explains a great mystery of Alzheimer’s, Parkinson’s
Setbacks in drug trials aiming to raise HDL have led researchers to reassess the particle’s effects on heart health. A study combining proteomics and mouse genetics may help researchers understand researchers understand the proteins in the particle, how they get there and how they determine HDL function.
View More Lipoproteins behave ‘almost like a tiny Velcro ball’
A new discovery has shed light on small RNAs called microRNAs in the liver that regulate fat and glucose metabolism. Research shows that a molecular anticipation, during fast to re-feed transition, is essential for capping glucose production by the liver. This novel control enables a rapid switch in physiology following food consumption. Besides the therapeutic potential, the findings show that these mechanisms may be associated with metabolic diseases and aging.
View More Micro-control of liver metabolism
Researchers have developed a new gene therapy to help decelerate the aging process. The findings highlight a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome, a rare genetic disorder that also afflicts humans.
View More CRISPR/Cas9 therapy can suppress aging, enhance health and extend life span in mice
A new antimicrobial-resistance gene, VCC-1, a beta-lactamase gene, has been discovered in benign close relatives of virulent Vibrio cholerae, which causes cholera. Now, a team of Canadian researchers has found a way to block the VCC-1 enzyme, which disables that resistance gene.
View More How to block new antibiotic resistance gene