Investigators have found evidence that the gene Ccdc117 supports the rapid growth of precursor cells needed for proper development of right-sided heart structures. It does so by promoting transfer of iron-sulfur compounds to enzymes crucial for DNA replication and repair. Silencing Ccdc117 impedes cell growth, which may prevent heart structures from developing properly.
The oldest publicly available strain of the cholera-causing bacterial species, Vibrio cholerae, has had its genetic code read for the first time. The bacterium was isolated from a British soldier during World War One (WWI) and stored for over 100 years before being revived and sequenced. The results show that this strain is a unique, non-toxigenic strain of V. cholerae that’s distantly related to the strains of bacteria causing cholera pandemics today and in the past.
Bhatia’s team spent more than six years delving down to the cellular level to examine what they say are previously overlooked cells that form on the edges of pluripotent stem cell colonies. Having characterized these cells, the team also observed them form at the earliest stages of pluripotent cell reprogramming from adult cells.
Scientists have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR/Cas9 and a seldom-used DNA repair pathway. This approach to programmable gene editing overcomes prior inefficiencies in gene correction.
Using a novel optical imaging technique, researchers discovered connections between the macromolecular structure and dynamic movement of chromatin within eukaryotic cells.
Researchers have found that RssB — a protein that specifically recognizes a critical stress-response master regulator in bacteria and delivers it to the recycling machinery somewhat like a recycling truck — forms a compact structure with a factor that inhibits RssB activity. The inhibition factor, called IraD, is triggered by DNA damage, one of many stresses the master regulator helps bacteria survive by turning on important genes.
Newly published research reveals some interesting, surprising and reassuring data about how one human body adapted to — and recovered from — the extreme environment of space.
A medical researcher has made it his mission to figure out why leukemia treatments cure some patients but not others. He and his team report progress on two important fronts: They shed light on how leukemia cells become resistant to drugs, and they describe how two drugs used in combination may overcome that resistance, offering new hope to thousands of children and adults with leukemia.
Biomedical engineers have developed a method for improving the accuracy of the CRISPR genome editing technology by an average of 50-fold. The approach adds a short tail to the guide RNA that folds back and binds onto itself, creating a ‘lock’ that can only be undone by the targeted DNA sequence.
Scientists have developed a catalogue of DNA mutation ‘fingerprints’ that could help doctors pinpoint the environmental culprit responsible for a patient’s tumor – including showing some of the fingerprints left in lung tumors by specific chemicals found in tobacco smoke.