The timing of food intake is a major factor driving the rhythmic expression of most genes in the mouse liver, researchers report. The findings demonstrate that body-wide signals driven by rhythmic food intake significantly contribute to driving rhythms in liver metabolic functions and gene expression independently of the liver and clock.
A medical researcher has made it his mission to figure out why leukemia treatments cure some patients but not others. He and his team report progress on two important fronts: They shed light on how leukemia cells become resistant to drugs, and they describe how two drugs used in combination may overcome that resistance, offering new hope to thousands of children and adults with leukemia.
Scientists have discovered how a family of proteins that regulates the activity of transposable elements in the genome allows them to make inheritable changes to the growing fetus.
Scientists have uncovered a process in cells that prevents DNA from becoming tangled, which resembles a method used to control climbers’ ropes.
Progress in understanding the genetic mutation responsible for Huntington’s disease (HD) and at least some molecular underpinnings of the disease has resulted in a new era of clinical testing of potential treatments. How best to design clinical trials in which HD patients are willing to participate and comply is a question faced by researchers.
Researchers found that the gene sirtuin 6 (SIRT6) is responsible for more efficient DNA repair in species with longer lifespans. The research illuminates new targets for anti-aging interventions and could help prevent age-related diseases.
Researchers describe a new set of ‘rules’ that predict how the tissue of origin influences critical aspects of the genetic makeup of tumors, with potentially important therapeutic implications.
After 20 years of dedicated research, scientists have cracked the chemical code of an incredibly complex ‘anti-tumor antibiotic’ known to be highly effective against cancer cells as well as drug-resistant bacteria, and have reproduced it synthetically in the lab for the first time.