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In mice, feeding time influences the liver’s biological clock

April 28, 2019 dna 0
The timing of food intake is a major factor driving the rhythmic expression of most genes in the mouse liver, researchers report. The findings demonstrate that body-wide signals driven by rhythmic food intake significantly contribute to driving rhythms in liver metabolic functions and gene expression independently of the liver and clock.
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Probing the mystery of drug resistance: New hope for leukemia’s toughest cases

April 28, 2019 dna 0
A medical researcher has made it his mission to figure out why leukemia treatments cure some patients but not others. He and his team report progress on two important fronts: They shed light on how leukemia cells become resistant to drugs, and they describe how two drugs used in combination may overcome that resistance, offering new hope to thousands of children and adults with leukemia.
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When designing clinical trials for Huntington’s disease, first ask the experts

April 27, 2019 dna 0
Progress in understanding the genetic mutation responsible for Huntington’s disease (HD) and at least some molecular underpinnings of the disease has resulted in a new era of clinical testing of potential treatments. How best to design clinical trials in which HD patients are willing to participate and comply is a question faced by researchers.