An effective sweeper closes DNA replication cycling

Scientists reported a novel molecular mechanism for the regulation of PCNA cycling during DNA replication. They proved that ATAD5-RLC opens PCNA ring to be removed from DNA as a bona-fide PCNA unloader. Since uncontrolled disassembly of replication machineries causes genomic instability that may result in cellular transformation, this study will be beneficial to develop strategies for cancer treatment.