New possibilities for gene therapies with spin of the Sleeping Beauty transposase

Scientists have developed a new variant of the Sleeping Beauty transposase. It has dramatically improved biochemical features, including enhanced stability and intrinsic cell penetrating properties. This transposase can be used for genome engineering of stem cells and therapeutic T cells. As such it is extremely valuable for use in regenerative medicine and cancer immunotherapy. The underlying genome engineering procedures will in the future also reduce costs and improve the safety of genome modifications.