Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation.

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Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation.

Circ Res. 2018 04 27;122(9):1176-1190

Authors: Roden DM, Van Driest SL, Wells QS, Mosley JD, Denny JC, Peterson JF

Abstract
This review will provide an overview of the principles of pharmacogenomics from basic discovery to implementation, encompassing application of tools of contemporary genome science to the field (including areas of apparent divergence from disease-based genomics), a summary of lessons learned from the extensively studied drugs clopidogrel and warfarin, the current status of implementing pharmacogenetic testing in practice, the role of genomics and related tools in the drug development process, and a summary of future opportunities and challenges.

PMID: 29700066 [PubMed – indexed for MEDLINE]