Origin of personalized medicine in pioneer, passionate, genomic research.
Genomics. 2019 May 09;:
Authors: Barrera-Saldaña HA
Personalized medicine, one of the main promises of the Human Genome Project (HGP) that initiated three decades ago, is now a new paradigm of medicine. With its arrival ended the era of developing drugs intended to suit all patients, often having to withdraw a promising new one because a minority of patients was at risk, even though it had been proven valuable for most; as well as the era of trial-and-error strategies being the only option to tailor therapy. But how did it originate? What are its beginnings? Is it true that the first personalized diagnostic test was the companion test for Herceptin®? In this account of an amazing journey from genomic and translational research to therapeutic and diagnostic innovations, I will recount how sequencing the human growth hormone (hGH) locus proved the concept of the feasibility of the HGP; demonstrating the value of having sequenced this locus to respond to the challenges of skeptical clinicians questioning such value by biomanufacturing HGH and then devising a test capable of predicting, among patients, which would respond to its administration. This companion diagnostics, created four years before the invention of the HercepTest® (registered as the first companion diagnostics ever developed). By cultivating genomic research with passion and pursuing its applications, we and many others contributed to the emergence of a new diagnostic industry, discovering better actionable gene-targets and to a renewed pharmaceutical industry developing more efficacious and safe drugs. In conjunction, they are offering each patient the opportunity to adopt the right treatment at the correct dosage in an opportune manner.
PMID: 31078717 [PubMed – as supplied by publisher]