The vast majority of patients with neurodegenerative disorders do not have specific gene mutations, but a single misbehaving protein — called TDP-43 — seems to be at the heart of these diseases. Researchers have found a way to recreate and rescue TDP-43 pathology in a dish.
A new study finds that samples of Candida albicans from patients frequently lack one copy of a vital master regulator, which gives them flexibility to lose the other copy and adapt to different environments.
A meta-analysis of multiple studies into the genetic background of Tourette’s syndrome (TS) — a neurodevelopmental disorder characterized by chronic involuntary motor and vocal tics — finds that variants in hundreds of genes, working in combination, contribute to the development of the syndrome and suggests that Tourette’s is part of a continuous spectrum of tic disorders, ranging from mild, sometimes transient tics to severe cases that can include psychiatric symptoms.
Our brain comprises 85 billion nerve cells and just as many so-called glial cells. But what decides when and how many of them become neurons or glial cells? A new study has shown how the Foxg1 gene plays a fundamental role in piloting the differentiation of stem cells, guaranteeing that neurons and glial cells are produced in the right quantity and at the right moment. The research opens new roads to understanding and treating incurable genetic diseases.
Scientists have identified the mistake-rate of DNA editing tools, based on CRISPR and known as adenine base editors. Assessing the genome-wide target specificity of these innovative techniques is essential to harness their applications in clinics and biotechnology.
Researchers have discovered how a tiny molecule known as miR-132 acts as a ‘handbrake’ on our immune system — helping us fight infection.
New research confirms in a nonhuman primate model that mosaic embryos can adapt to their abnormalities and persist in development, resulting in positive IVF outcomes.