One of the great mysteries of neuroscience may finally have an answer: Scientists have identified a potential explanation for the mysterious death of specific brain cells seen in Alzheimer’s, Parkinson’s and other neurodegenerative diseases.
Bacteria in the gut do far more than help digest food in the stomachs of their hosts; they can also tell the genes in their mammalian hosts what to do. A study describes a form of ‘interspecies communication’ in which bacteria secrete a specific molecule — nitric oxide — that allows them to communicate with and control their hosts’ DNA, and suggests that the conversation between the two may broadly influence human health.
Fat cells in the human body have their own internal clocks and exhibit circadian rhythms affecting critical metabolic functions, new research finds.
Physician-scientists have identified the cause of a devastating pediatric brain disorder paving the way for the first step in developing potential therapies for this rare neurodegenerative condition.
Researchers have discovered a new and rare skeletal disease. They describe the molecular mechanism of the disease, in which small RNA molecules play a role that has never before been observed in a congenital human disease. The results are important for affected patients but can also help scientists to understand other rare diagnoses.
The Argonaute (Ago) enzyme complex plays a critical role in DNA and RNA target cleavage for a process known as RNA silencing in prokaryotic and eukaryotic cells, making them a target for future gene-editing technology. The present study unravels key differences between prokaryotic Ago (pAgo) and eukaryotic Ago (eAgo) enzymes in the cleavage reaction and may provide important clues on their evolutionary past.
Researchers have identified one of the main mechanisms behind the repair of serious damage to the human DNA.
A previously unknown messenger which alarms nearby cells when the immune system recognizes a bacterial or viral infection has been uncovered.
Neuroscientists have used CRISPR/Cas9 genome editing technology to regulate genes in the rat brain. This technique paves the way for researchers to probe genetic influences on brain health and disease in model organisms that more closely resemble human conditions.
Scientists report a new and improved method to detect chemical modifications to DNA. These modifications — or ‘epigenetic’ marks — help control gene expression and their aberrant distribution across the genome contributes to cancer progression and resistance to therapy.