Scientists have developed a catalogue of DNA mutation ‘fingerprints’ that could help doctors pinpoint the environmental culprit responsible for a patient’s tumor – including showing some of the fingerprints left in lung tumors by specific chemicals found in tobacco smoke.
Biomedical engineers have developed a method for improving the accuracy of the CRISPR genome editing technology by an average of 50-fold. The approach adds a short tail to the guide RNA that folds back and binds onto itself, creating a ‘lock’ that can only be undone by the targeted DNA sequence.
A medical researcher has made it his mission to figure out why leukemia treatments cure some patients but not others. He and his team report progress on two important fronts: They shed light on how leukemia cells become resistant to drugs, and they describe how two drugs used in combination may overcome that resistance, offering new hope to thousands of children and adults with leukemia.
The timing of food intake is a major factor driving the rhythmic expression of most genes in the mouse liver, researchers report. The findings demonstrate that body-wide signals driven by rhythmic food intake significantly contribute to driving rhythms in liver metabolic functions and gene expression independently of the liver and clock.
Glioblastoma is one of the most devastating forms of cancer, with few existing treatment options. It is also a leading cause of cancer-related death in children and young adults. Scientists have ‘reverse engineered’ brain cancer stem cells gene by gene, uncovering multiple potential targets for this hard-to-treat cancer.
Scientists have discovered how a family of proteins that regulates the activity of transposable elements in the genome allows them to make inheritable changes to the growing fetus.
Scientists have uncovered a process in cells that prevents DNA from becoming tangled, which resembles a method used to control climbers’ ropes.
Researchers found that the gene sirtuin 6 (SIRT6) is responsible for more efficient DNA repair in species with longer lifespans. The research illuminates new targets for anti-aging interventions and could help prevent age-related diseases.
Progress in understanding the genetic mutation responsible for Huntington’s disease (HD) and at least some molecular underpinnings of the disease has resulted in a new era of clinical testing of potential treatments. How best to design clinical trials in which HD patients are willing to participate and comply is a question faced by researchers.