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New ‘interspecies communication’ strategy between gut bacteria and mammalian hosts uncovered

February 25, 2019 dna 0
Bacteria in the gut do far more than help digest food in the stomachs of their hosts; they can also tell the genes in their mammalian hosts what to do. A study describes a form of ‘interspecies communication’ in which bacteria secrete a specific molecule — nitric oxide — that allows them to communicate with and control their hosts’ DNA, and suggests that the conversation between the two may broadly influence human health.
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New skeletal disease found and explained

February 25, 2019 dna 0
Researchers have discovered a new and rare skeletal disease. They describe the molecular mechanism of the disease, in which small RNA molecules play a role that has never before been observed in a congenital human disease. The results are important for affected patients but can also help scientists to understand other rare diagnoses.
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Key differences between prokaryotic and eukaryotic RNA silencing Argonaute enzyme unveiled

February 25, 2019 dna 0
The Argonaute (Ago) enzyme complex plays a critical role in DNA and RNA target cleavage for a process known as RNA silencing in prokaryotic and eukaryotic cells, making them a target for future gene-editing technology. The present study unravels key differences between prokaryotic Ago (pAgo) and eukaryotic Ago (eAgo) enzymes in the cleavage reaction and may provide important clues on their evolutionary past.