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Scientists capture a ‘snapshot’ of bacterial stress-response regulator’s ‘recycling truck’

April 21, 2019 dna 0
Researchers have found that RssB — a protein that specifically recognizes a critical stress-response master regulator in bacteria and delivers it to the recycling machinery somewhat like a recycling truck — forms a compact structure with a factor that inhibits RssB activity. The inhibition factor, called IraD, is triggered by DNA damage, one of many stresses the master regulator helps bacteria survive by turning on important genes.
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Probing the mystery of drug resistance: New hope for leukemia’s toughest cases

April 21, 2019 dna 0
A medical researcher has made it his mission to figure out why leukemia treatments cure some patients but not others. He and his team report progress on two important fronts: They shed light on how leukemia cells become resistant to drugs, and they describe how two drugs used in combination may overcome that resistance, offering new hope to thousands of children and adults with leukemia.
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In mice, feeding time influences the liver’s biological clock

April 21, 2019 dna 0
The timing of food intake is a major factor driving the rhythmic expression of most genes in the mouse liver, researchers report. The findings demonstrate that body-wide signals driven by rhythmic food intake significantly contribute to driving rhythms in liver metabolic functions and gene expression independently of the liver and clock.
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Scientists ‘reverse engineer’ brain cancer cells to find new targets for treatment

April 21, 2019 dna 0
Glioblastoma is one of the most devastating forms of cancer, with few existing treatment options. It is also a leading cause of cancer-related death in children and young adults. Scientists have ‘reverse engineered’ brain cancer stem cells gene by gene, uncovering multiple potential targets for this hard-to-treat cancer.
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Direct-to-Consumer Genetic Testing’s Red Herring: “Genetic Ancestry” and Personalized Medicine.

April 21, 2019 dna 0
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Direct-to-Consumer Genetic Testing’s Red Herring: “Genetic Ancestry” and Personalized Medicine.

Front Med (Lausanne). 2019;6:48

Authors: Blell M, Hunter MA

Abstract
The growth in the direct-to-consumer genetic testing industry poses a number of challenges for healthcare practice, among a number of other areas of concern. Several companies providing this service send their customers reports including information variously referred to as genetic ethnicity, genetic heritage, biogeographic ancestry, and genetic ancestry. In this article, we argue that such information should not be used in healthcare consultations or to assess health risks. Far from representing a move toward personalized medicine, use of this information poses risks both to patients as individuals and to racialized ethnic groups because of the way it misrepresents human genetic diversity.

PMID: 30984759 [PubMed]