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Learning from nature’s bounty: New libraries for drug discovery

June 16, 2019 dna 0
Natural products make some of our most potent medicines, among which macrocycles with their large carbon-rich ring systems are one class. Their size and complexity has made it difficult to emulate on Nature’s success in the laboratory. By completing a complex molecular synthesis of these compounds attached to a unique identifying DNA strand, Chemists have built a rich collection of natural product-like macrocycles that can be mined for new medicines.
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Viruses found to use intricate ‘treadmill’ to move cargo across bacterial cells

June 16, 2019 dna 0
Using advanced technologies to explore the inner workings of bacteria, biologists have provided the first example of cargo within bacteriophage cells transiting along treadmill-like structures. The discovery demonstrates that bacteria have more in common with sophisticated human cells than previously believed.
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Using genetic genealogy databases in missing persons cases and to develop suspect leads in violent crimes.

June 16, 2019 dna 0
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Using genetic genealogy databases in missing persons cases and to develop suspect leads in violent crimes.

Forensic Sci Int. 2019 May 14;301:107-117

Authors: Kennett D

Abstract
In the last year direct-to-consumer (DTC) genetic genealogy databases have been used to identify suspects and missing persons in over fifty cold cases, many of which have been unsolved for decades. Genealogists worked on these cases in collaboration with law enforcement agencies. Raw DNA data files were uploaded to the genealogy websites GEDmatch and FamilyTreeDNA, and identification was made by tracing the family trees of relatives who were predicted to be close genetic matches in the database. Such searches have far-reaching consequences because they affect not just those who have consented to upload their DNA results to these databases but also all of their relatives, regardless of whether or not they have taken a DNA test. This article provides an overview of the methods used, the potential privacy and security issues, and the wider implications for society. There is an urgent need for forensic scientists, bioethicists, law enforcement agencies, genetic genealogists and other interested parties to work together to produce international guidelines and policies to ensure that the techniques are used responsibly and effectively.

PMID: 31153988 [PubMed – as supplied by publisher]