A team of investigators has discovered a new, more powerful variant on an antimicrobial resistance gene common among Staphylococcus species. The gene protects the bacteria from an antiseptic compound widely used in healthcare. The team showed that the newly discovered gene occurs in a highly virulent and multi-resistant clone of Staphylococcus epidermidis, found in healthcare settings worldwide.
Hematology researchers have further refined how a treatment currently used on an urgent basis to control bleeding in hemophilia patients holds promise as a preventive treatment as well. A study in animals may set the stage for a new therapy for a subset of patients with hemophilia who now develop antibodies to the standard maintenance treatment and then require on-demand ‘bypass’ therapy.
Genes play a role in determining the beauty of a person’s face, but that role varies with the person’s sex, according to a new study.
Researchers are reporting new findings on how bacteria involved in gum disease can travel throughout the body, exuding toxins connected with Alzheimer’s disease, rheumatoid arthritis and aspiration pneumonia. They detected evidence of the bacteria in brain samples from people with Alzheimer’s and used mice to show that the bacterium can find its way from the mouth to the brain.
Most children inherit both their postal code and their genetic code from their parents. But if genetic factors influence where families are able to live and children’s health and educational success, improving neighborhoods may not be enough. Latest research provides new insights into the highly debated question of whether the neighborhoods that children live in influence their health and life chances.
An international team has unveiled a new CRISPR-based tool that acts more like a shredder than the usual scissor-like action of CRISPR-Cas9. The new approach, based on Type I CRISPR-Cas3, is able to wipe out long stretches of DNA in human cells with programmable targeting, and has been shown to work in human cells for the first time.
Scientists developed a new version of a gene drive that allows the spread of specific, favorable genetic variants, also known as ‘alleles,’ throughout a population. The new ‘allelic drive’ is equipped with a guide RNA that directs CRISPR to cut undesired variants of a gene and replace it with a preferred version. Using a word processing analogy, CRISPR-based gene drives allow scientists to edit sentences of genetic information, while the new allelic drive offers letter-by-letter editing.