Incorporating genetic diversity into a mouse model of Alzheimer’s disease resulted in greater overlap with the genetic, molecular and clinical features of this pervasive human disease, according to a new study.
Helping the immune system clear away old cells in aging mice helped restore youthful characteristics.
A ground-breaking new study has succeeded in compiling an atlas of genetic factors associated with estimated bone mineral density (BMD), one of the most clinically relevant factors in diagnosing osteoporosis. The paper identifies 518 genome-wide loci, of which 301 are newly discovered, that explain 20 percent of the genetic variance associated with osteoporosis.
With their small size, stubby faces and wide-set eyes, bulldogs, French bulldogs and Boston terriers are among the most popular of domestic dog breeds. Now researchers have found the genetic basis for these dogs’ appearance, and linked it to a rare inherited syndrome in humans.
Scientists made hollow nanosized boxes with corner holes, demonstrating how these ”nanowrappers” can carry and release DNA-coated nanoparticles.
Researchers have developed new bioinspired material that interacts with surrounding tissues to promote healing.
A scientist has called for Australia to embrace pharmacogenetic (PGx) testing to deliver medication more effectively and slash around $2.4 billion wasted each year through unsafe and ineffective drug prescriptions.
Elongated segments of DNA cause Huntington’s disease and certain other disorders of the brain. Researchers have developed a method to determine the length of the mutated genes quickly and easily.
Pairs of negatively charged phosphate groups and positive magnesium ions represent a key structural feature of DNA and RNA embedded in water. Vibrations of phosphate groups have now been established as selective probes of such contact pairs and allow for a mapping of interactions and structure on the ultrafast time scales of molecular dynamics.
Distinguishing between left-handed and right-handed (‘chiral’) molecules is crucial in chemistry and the life sciences, and is commonly done using a method called circular dichroism. However, during biochemical reactions the chiral character of molecules may change. Scientists have for the first time developed a method that uses ultrashort deep-ultraviolet pulses to accurately probe such changes in real-time in (bio)molecular systems.