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Decades-old question about protein found in Alzheimer’s brain plaques

January 12, 2019 dna 0
Alzheimer’s-affected brains are riddled with so-called amyloid plaques: protein aggregates consisting mainly of amyloid-beta. However, this amyloid-beta is a fragment produced from a precursor protein whose normal function has remained enigmatic for decades. A team of scientists has now uncovered that this amyloid precursor protein modulates neuronal signal transmission through binding to a specific receptor. Modulating this receptor could potentially help treat Alzheimer’s or other brain diseases.
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Researchers use ‘blacklist’ computing concept as novel way to streamline genetic analysis

January 12, 2019 dna 0
Researchers have discovered a new use for a long-standing computational concept known as ‘blacklisting.’ Using blacklisting as a filter to single out genetic variations in patient genomes and exomes that do not cause illness, researchers have successfully streamlined the identification of genetic drivers of disease.