Researchers have developed new bioinspired material that interacts with surrounding tissues to promote healing.
A scientist has called for Australia to embrace pharmacogenetic (PGx) testing to deliver medication more effectively and slash around $2.4 billion wasted each year through unsafe and ineffective drug prescriptions.
Elongated segments of DNA cause Huntington’s disease and certain other disorders of the brain. Researchers have developed a method to determine the length of the mutated genes quickly and easily.
Distinguishing between left-handed and right-handed (‘chiral’) molecules is crucial in chemistry and the life sciences, and is commonly done using a method called circular dichroism. However, during biochemical reactions the chiral character of molecules may change. Scientists have for the first time developed a method that uses ultrashort deep-ultraviolet pulses to accurately probe such changes in real-time in (bio)molecular systems.
Scientists have created an ‘on’ switch for CRISPR-Cas9 that allows it to be turned on in select cells only, specifically those that have a particular protein-cutting enzyme, or protease. Viruses produce such proteases, as do cancer cells, so the Cas9 variants — called ProCas9 — could be used as sensors for viral infections or cancer. The variants were discovered by circular permutations on wild-type Cas9 designed to produce a stripped-down Cas9 tuned to human cells.
Alzheimer’s-affected brains are riddled with so-called amyloid plaques: protein aggregates consisting mainly of amyloid-beta. However, this amyloid-beta is a fragment produced from a precursor protein whose normal function has remained enigmatic for decades. A team of scientists has now uncovered that this amyloid precursor protein modulates neuronal signal transmission through binding to a specific receptor. Modulating this receptor could potentially help treat Alzheimer’s or other brain diseases.