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Big change from small player: Mitochondria alter body metabolism and gene expression

November 11, 2018 dna 0
Mitochondria have their own DNA, but the 13 genes in human mitochondria — along with DNA sequences for tRNAs, rRNAs and some small peptides — are massively overshadowed by the 20,000 genes in the human nucleus. Nevertheless, these diminutive mitochondria may have a strong influence on cellular metabolism and susceptibility to metabolic diseases like heart failure or obesity.
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Defective DNA damage repair leads to chaos in the genome

November 11, 2018 dna 0
Scientists have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for a few years: If an important DNA repair system of the cells has failed, this promotes fragmentation and defective assembly of the genetic material. Cancer cells with such a repair defect can now possibly be treated by a specific group of drugs.