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How much are we learning about the genome? Natural selection is science’s best critic

January 7, 2019 dna 0
Even as they’ve struggled to highlight parts of the human genome worth investigating, scientists have wondered how much they’re actually learning through the methods they use. Now, two researchers have determined that natural selection and our own evolutionary history might be science’s best critics, and guides for future research.
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Parkinson’s disease protein buys time for cell repair

January 7, 2019 dna 0
Loss of the protein Parkin causes certain forms of Parkinson’s disease, a neurodegenerative condition involving death of neurons. Scientists have now shown that Parkin stifles cell death by blocking BAK, a protein which is a central player in cell death. Understanding the interactions between Parkin and BAK may lead to new therapeutic approaches to slow the progression of Parkinson’s disease.
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Age is more than just a number: Machine learning may predict if you’re in for a healthy old age

January 7, 2019 dna 0
Researchers analyzed skin cells from the very young to the very old and looked for molecular signatures that can be predictive of age. By applying machine-learning algorithms to these biomarkers, they were able to predict a person’s actual age with less than eight years error, on average.
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Researchers use ‘blacklist’ computing concept as novel way to streamline genetic analysis

January 7, 2019 dna 0
Researchers have discovered a new use for a long-standing computational concept known as ‘blacklisting.’ Using blacklisting as a filter to single out genetic variations in patient genomes and exomes that do not cause illness, researchers have successfully streamlined the identification of genetic drivers of disease.