A new study describes how researchers wirelessly controlled FGFR1 — a gene that plays a key role in how humans grow from embryos to adults — in lab-grown brain tissue. The ability to manipulate the gene, the study’s authors say, could lead to new cancer treatments, and ways to prevent and treat mental disorders such as schizophrenia.
Researchers have determined that a human gene present in 75% of the population is a key reason why a class of drugs for Alzheimer’s disease seemed promising in animal studies only to fail in human studies.
A psychologist asserts that those carrying the APOE4 gene score lower on IQ tests during childhood and adolescence. And the effect was stronger in girls than in boys. APOE4 carriers are up to three times more likely to develop late-onset Alzheimer’s disease, which occurs in people 65 and older.
In a study using yeast cells and data from cancer cell lines, scientists report they have found a potential weak spot among cancer cells that have extra sets of chromosomes, the structures that carry genetic material. The vulnerability, they say, is rooted in a common feature among cancer cells — their high intracellular protein concentrations — that make them appear bloated and overstuffed, and which could be used as possible new targets for cancer treatments.
UC San Diego researchers have used the transcriptome — the sum of all messenger RNA (mRNA) molecules expressed from genes — to map protein-gene interactions involved in Alzheimer’s disease.
Reseachers have found that fat cells play a key role in the dangerous transformation of melanoma.
The chemical interactions that give proteins their shape may be weaker and more numerous than previously recognized. Chemists modeled the building blocks of the protein structure that causes Alzheimer’s disease, amyloid beta sheets. Their calculations revealed that some atoms too far apart to bond were still in each other’s ‘electron neighborhoods.’