Scientists made hollow nanosized boxes with corner holes, demonstrating how these ”nanowrappers” can carry and release DNA-coated nanoparticles.
Researchers have developed new bioinspired material that interacts with surrounding tissues to promote healing.
A scientist has called for Australia to embrace pharmacogenetic (PGx) testing to deliver medication more effectively and slash around $2.4 billion wasted each year through unsafe and ineffective drug prescriptions.
Elongated segments of DNA cause Huntington’s disease and certain other disorders of the brain. Researchers have developed a method to determine the length of the mutated genes quickly and easily.
Distinguishing between left-handed and right-handed (‘chiral’) molecules is crucial in chemistry and the life sciences, and is commonly done using a method called circular dichroism. However, during biochemical reactions the chiral character of molecules may change. Scientists have for the first time developed a method that uses ultrashort deep-ultraviolet pulses to accurately probe such changes in real-time in (bio)molecular systems.
Scientists have created an ‘on’ switch for CRISPR-Cas9 that allows it to be turned on in select cells only, specifically those that have a particular protein-cutting enzyme, or protease. Viruses produce such proteases, as do cancer cells, so the Cas9 variants — called ProCas9 — could be used as sensors for viral infections or cancer. The variants were discovered by circular permutations on wild-type Cas9 designed to produce a stripped-down Cas9 tuned to human cells.
Alzheimer’s-affected brains are riddled with so-called amyloid plaques: protein aggregates consisting mainly of amyloid-beta. However, this amyloid-beta is a fragment produced from a precursor protein whose normal function has remained enigmatic for decades. A team of scientists has now uncovered that this amyloid precursor protein modulates neuronal signal transmission through binding to a specific receptor. Modulating this receptor could potentially help treat Alzheimer’s or other brain diseases.
Researchers have discovered a new use for a long-standing computational concept known as ‘blacklisting.’ Using blacklisting as a filter to single out genetic variations in patient genomes and exomes that do not cause illness, researchers have successfully streamlined the identification of genetic drivers of disease.
Incorporating genetic diversity into a mouse model of Alzheimer’s disease resulted in greater overlap with the genetic, molecular and clinical features of this pervasive human disease, according to a new study.