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Major genetic study confirms that many genes contribute to risk for Tourette’s syndrome

March 11, 2019 dna 0
A meta-analysis of multiple studies into the genetic background of Tourette’s syndrome (TS) — a neurodevelopmental disorder characterized by chronic involuntary motor and vocal tics — finds that variants in hundreds of genes, working in combination, contribute to the development of the syndrome and suggests that Tourette’s is part of a continuous spectrum of tic disorders, ranging from mild, sometimes transient tics to severe cases that can include psychiatric symptoms.
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Discovery of the genetic ‘conductor’ of brain stem cells

March 11, 2019 dna 0
Our brain comprises 85 billion nerve cells and just as many so-called glial cells. But what decides when and how many of them become neurons or glial cells? A new study has shown how the Foxg1 gene plays a fundamental role in piloting the differentiation of stem cells, guaranteeing that neurons and glial cells are produced in the right quantity and at the right moment. The research opens new roads to understanding and treating incurable genetic diseases.
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Potential new therapy for Crohn’s, colitis identified

March 11, 2019 dna 0
Researchers have found a compound that may treat inflammatory bowel disease without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting. They discovered that the gene was turned on at sites of intestinal inflammation and damage, and blocking its activity reduces IBD symptoms in mice.
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When a cell’s ‘fingerprint’ can be a weapon against cancer

March 11, 2019 dna 0
A research team has computationally analyzed the expression of marker genes that are associated with a ‘fingerprint’ of cancer cells in thousands of tumors and revealed its therapeutic potential in the fight against cancer. The study shows the types of tumors in which these genes are most active and identifies drugs with the potential to selectively eliminate cells that carry that label.
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Gene behind long-recognized mitochondrial disease has highly varied effects

March 11, 2019 dna 0
Mutations in the mitochondrial gene mt-ATP6, which encodes an essential part of the mitochondrial motor known as ATP synthase that generates cellular energy, are much more variable than previously thought. This prompts the need to develop more precise clinical tests that can better determine the course of treatment for patients affected by mitochondrial disorder.