A new study finds that samples of Candida albicans from patients frequently lack one copy of a vital master regulator, which gives them flexibility to lose the other copy and adapt to different environments.
A meta-analysis of multiple studies into the genetic background of Tourette’s syndrome (TS) — a neurodevelopmental disorder characterized by chronic involuntary motor and vocal tics — finds that variants in hundreds of genes, working in combination, contribute to the development of the syndrome and suggests that Tourette’s is part of a continuous spectrum of tic disorders, ranging from mild, sometimes transient tics to severe cases that can include psychiatric symptoms.
Our brain comprises 85 billion nerve cells and just as many so-called glial cells. But what decides when and how many of them become neurons or glial cells? A new study has shown how the Foxg1 gene plays a fundamental role in piloting the differentiation of stem cells, guaranteeing that neurons and glial cells are produced in the right quantity and at the right moment. The research opens new roads to understanding and treating incurable genetic diseases.
Scientists have identified the mistake-rate of DNA editing tools, based on CRISPR and known as adenine base editors. Assessing the genome-wide target specificity of these innovative techniques is essential to harness their applications in clinics and biotechnology.
Researchers have discovered how a tiny molecule known as miR-132 acts as a ‘handbrake’ on our immune system — helping us fight infection.
New research confirms in a nonhuman primate model that mosaic embryos can adapt to their abnormalities and persist in development, resulting in positive IVF outcomes.
After analyzing tens of thousands of data samples, researchers have created a list of genes that ranks them based on how frequently they are implicated in specific diseases. The list may prove invaluable for future research and drug discovery.
Researchers have found a compound that may treat inflammatory bowel disease without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting. They discovered that the gene was turned on at sites of intestinal inflammation and damage, and blocking its activity reduces IBD symptoms in mice.
A research team has computationally analyzed the expression of marker genes that are associated with a ‘fingerprint’ of cancer cells in thousands of tumors and revealed its therapeutic potential in the fight against cancer. The study shows the types of tumors in which these genes are most active and identifies drugs with the potential to selectively eliminate cells that carry that label.
Mutations in the mitochondrial gene mt-ATP6, which encodes an essential part of the mitochondrial motor known as ATP synthase that generates cellular energy, are much more variable than previously thought. This prompts the need to develop more precise clinical tests that can better determine the course of treatment for patients affected by mitochondrial disorder.