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Drug design: Clues for drugging the ‘undruggable’

November 12, 2018 dna 0
Scientists have shown how thalidomide analogs mediate degradation of many more proteins than previously anticipated. These proteins — zinc finger transcription factors — play a role in cancer and developmental diseases but are difficult drug targets. The new study suggests that thalidomide analogs can be rationally designed to target this challenging class of proteins.
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Trying to understand cells’ interior design

November 12, 2018 dna 0
Scientists have explained how liquid-like droplets made of proteins and DNA form in vitro. Currently, there is a huge interest in understanding the molecular mechanisms behind the creation of such droplets, as it is linked to some human diseases, such as amyotrophic lateral sclerosis (ALS). The results showed how much the sequence of DNA matters in the formation of such droplets.
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World’s most comprehensive digital roadmap to unlock male infertility

November 12, 2018 dna 0
Millions of couples who have trouble conceiving may get relief from new research. The researchers have developed a high-resolution genetic map showing how men produce sperm cells. Their effort could help address genetically based challenges with male fertility, a major cause of conception problems.