Role of HPV DNA testing in modern gynaecological practice.

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Role of HPV DNA testing in modern gynaecological practice.

Best Pract Res Clin Obstet Gynaecol. 2018 Feb;47:107-118

Authors: Ronco G, Giorgi Rossi P

Abstract
The identification of some types of human papillomavirus (HPV) as necessary, but not sufficient, cause of cervical cancer has suggested the use of HPV testing in cervical cancer prevention. A large number of studies has provided evidence supporting its application (1) as primary screening test, (2) for triaging borderline cytology, (3) for follow-up after positive primary test but no abnormal histology and (4) as a test of cure. They also allowed a reasonably good definition of the appropriate policies and protocols, leading to the delivery of evidence-based guidelines resulting from a systematic review of the literature. In this chapter, we present a critical analysis of the recommendations of the main European and North American guidelines relative to industrialised countries.

PMID: 28918099 [PubMed – indexed for MEDLINE]